Faculty developed a simulation-based experience (SBE) to translate didactic opioid and nonopioid analgesic concepts to clinical practice while improving first-semester nursing students' abilities to perform medication reconciliation (MR) to reduce drug errors. Approximately 150 prelicensure students participated in the MR SBE. The SBE included a scenario-based case that involved a client at a point of transition in care requiring MR. Students used role-play to engage in the process of MR with a focus on analgesic medications and reducing the risk for medication errors. Students worked together to reconcile a complete list of home medications by interviewing the patient, assessing a patient-provided list of home medications, and inspecting a patient-provided bag of medication bottles. After completing the MR, students interpreted the complexities of the list of home medications and identified any risk for drug errors. The primary medications listed on the patient's home medication list were analgesics such as opioids, nonopioid over-the-counter medications including nonsteroidal anti-inflammatory drugs, and adjuvants for migraines and gout pain. This activity bridged content learned in didactic class to clinical practice and strengthened critical thinking and clinical reasoning. One student's feedback included that the activity led students to "research the drugs that we are learning about and find out the details and interactions of them."