Abstract
This study evaluated the efficacy of online versus instructor-led advanced cardiac life support for first-time registered nurse participants. Participants were randomized into online or instructor-led courses, with learning outcomes measured in the cognitive, psychomotor, and affective domains. The instructor-led group showed statistically significant better performance during simulated megacode. Further analysis identified key areas where instructor-led participants out-performed the online group, enabling educators to articulate risk and benefit of the two learning modalities.