Abstract
Overview: The evolution of HIV infection into a chronic disease has implications across all clinical care settings. Every nurse should be knowledgeable about the prevention, testing, treatment, and chronicity of the disease in order to provide high-quality care to people with or at risk for HIV. It's important, therefore, to have an understanding of the changing epidemiology of the disease, the most recent testing recommendations, developments in screening technology, the implications of aging with HIV infection, and the nursing implications of the ongoing epidemic.