Abstract
Postoperative pain in total knee arthroplasty is a challenge that affects the facets of an optimal recovery process. Adequate pain management can be achieved with traditional methods, such as parenteral opioids, epidural analgesic, and peripheral nerve blocks, but is often associated with disruptive side effects, mostly attributed to the opioids. Periarticular multimodal drug injection is an efficient alternative form of postoperative analgesia with minimal risk for opioid-related side effects. The purpose of this article is to describe the use and effectiveness of periarticular multimodal drug injection for postoperative pain management and accentuate the potential consequent effects of effective pain control. Comparative differentiation of this method with other forms of pain management modality is illustrated with strong emphasis on safety and efficacy.