Abstract
PURPOSE: The purpose of this study was to assess the changes in standard lipid measures such as total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in comparison with changes in non-HDL-C.
Methods: Data from 100 participants in a phase II cardiac rehabilitation program at entry and 12 weeks were assessed for changes in lipid measures. Eighty-six percent of participants were on stable lipid therapy throughout the 12-week period. Participants were classified as meeting or not meeting optimal levels of LDL-C, HDL-C, and non-HDL-C. Differences in classification for each measure were compared using the Fisher exact tests.
Results: Changes in total cholesterol and LDL-C were not significant (P = .24 and P = .23, respectively). There was a significant increase in HDL-C (2.22 +/- 0.97 mg/dL, P = .0243). Non-HDL-C and triglycerides tended to decrease but did not reach significance (P = .08 and P = .96, respectively). At baseline, non-HDL-C classified a significantly higher number of participants as none optimal than did LDL-C (P < .0001). At the 12-week follow-up, a significantly higher number of participants were classified as optimal by non-HDL-C measures than by LDL-C (P < .0001).
Conclusions: Non-HDL-C provides additional information to that of standard lipid measures in secondary prevention. Non-HDL-C independently classifies risk levels of participants and is responsive to traditional rehabilitation.