The World Health Organization warns of a high global cholera risk. This risk has rapidly worsened since mid-2021, with 24 countries reporting active outbreaks as of March 2023. Numbers are also expected to increase, as March is typically a low or interepidemic transmission period for many regions. The situation is alarming because outbreaks have spread to countries that have not seen cholera cases in decades, and mortality rates across all countries are the highest recorded in more than 10 years. Adding to the concern is a hampered public health response as the result of multiple outbreaks; ongoing humanitarian crises in affected countries; climate change; and lack of resources, including not enough oral cholera vaccine due to a global shortage.