Abstract
Glioblastoma multiforme (GBM) is one of the most aggressive malignancies and primarily arises intracranially. It rarely coexists with other tumors. Here, we report an anomalous case of a patient who had GBM combined with a bone tumor of the femur. As new treatment options have been developed, the survival rate of patients with GBM has increased incrementally; thus, clinicians will encounter patients with extracranial metastases or combined with other diseases. Although extracranial GBM metastases and GBM combined with other tumors are rare, comprehensive whole-body evaluations are needed for proper management and therapeutic strategies.