Abstract
Central venous access devices are indispensable tools in caring for the gravely ill patients in today's critical care units. Unfortunately, they are also one of the major sources for nosocomial infections in the hospital setting. This article explores the pathophysiology and risk factors related to central venous access devices infections, and examine prevention strategies. The critical care nurse, using evidence-based practice guidelines in the care of these lines, can be instrumental in preventing catheter-related infections.