The novel coronavirus (COVID-19) has led to the need for rapid change in clinical and academic settings. The COVID-19 pandemic is a unique opportunity to allow practicing nurses to deepen their understanding of the disease process, treatment, and safe practice related to infection control. RNs enrolled in our online RN-to-BSN program taking the pathophysiology/pharmacology course received instruction on inflammation and immunity in one of the course modules. The module was updated to include a video on the COVID-19 disease process, a review of how vaccines work, and pharmacotherapy considerations for adults and children with COVID-19. Nurses were then provided with a case study involving an adult patient with COVID-19 treated in the hospital setting. Next, they submitted a paper to demonstrate the ability to relate the pathophysiology of COVID-19 to pharmacotherapy and nursing considerations. Finally, they were asked to reflect on how the assignment impacted their current practice. Nurses expressed several benefits of the teaching strategy. First, they appreciated the opportunity to research evidence-based practice and review literature from trusted sources because inconsistent reports from the media and politicians can overwhelm and incite fear. Second, nurses reported increased confidence in collaborating with physicians and interdisciplinary teams, advocating for their patients' needs, and empowering families to cope. Finally, nurses expressed increased confidence in assessing patients' perspectives about vaccines. Exposing the practicing nurse to evidence-based treatment guidelines strengthens their knowledge base and improves patient outcomes.