Global sepsis cases double, many in young children. In 2017, sepsis killed 11 million people worldwide, twice as many as previously thought, according to a study in the January 18 Lancet. Sepsis accounts for one in five deaths globally with more than 40% of cases occurring in children younger than five years and living in poverty. The authors called for renewed efforts to fight antimicrobial resistance and sepsis in newborns-both drivers of the surging global problem. International guidelines for the management of sepsis in children are now available from the Surviving Sepsis Campaign (see http://www.sccm.org/SurvivingSepsisCampaign/Home).