Abstract
Nosocomial bloodstream infections continue to be a major cause of morbidity and mortality. Approximately 8% of all nosocomial infections reported in the United States are primarily bloodstream infections. These infections prolong hospital length of stay, increase mortality, and raise the overall cost of healthcare. A contaminated infusate administered through a central venous catheter is one of the commonly identified causes of nosocomial bacteremia. In most cases, contamination of the infusate occurs extrinsically during manipulation of the fluid before its administration to the patient. Failure to use aseptic technique and poor hand washing often are the cause. In addition to improved staff education, surveillance for nosocomial bloodstream infections continues to be the cornerstone of prevention.