DUBLIN, IRELAND-A combination of two drugs, which prompt the body's immune system to identify and kill cancer cells, is a safe treatment for patients with advanced non-small cell lung cancer (NSCLC) and has shown some signs of efficacy (Abstract 8).
Results from a phase I/II clinical trial in 25 patients, presented at the 2018 EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, identified the maximum tolerated doses at which NIR178 (PBF-509) and spartalizumab (PDR001) could be given to patients whose disease had either failed to respond or stopped responding to previous treatments. The disease shrank or disappeared in two patients and it remained stable, without progressing, in 14 patients.
Tumors are surrounded by blood vessels, normal cells, and molecules that make up the tumor's microenvironment. To grow and spread, tumors recruit various molecules to suppress the body's immune system, which would otherwise recognize and kill cancer cells. Adenosine is one molecule that suppresses the immune system in the tumor microenvironment, but previous research has shown that its activity can be blocked by NIR178. Spartalizumab is a monoclonal antibody that blocks PD-1, a molecule that acts as a checkpoint to regulate the immune response.
Researchers, led by Alberto Chiappori, MD, Senior Member of Oncology and Medicine for the Thoracic Oncology Program at Moffitt Cancer Center, Tampa, Fla., wanted to investigate whether the combination of these two immunotherapies might be more effective against NSCLC than either drug on its own.
Study Specifics
Between August 2016 and January 2018, the study enrolled 25 patients with advanced NSCLC who had been treated already with at least one therapy and either failed to respond or relapsed.
"Most of these patients were heavily pre-treated with chemotherapy, radiation, and immunotherapy," noted Chiappori. However, they were still fairly fit, being either fully active with everyday life unaffected by their disease or restricted in physically strenuous activity but able to carry out work of a light or sedentary nature (ECOG performance status 0-1). The average age was 64, 60 percent were men, and 44 percent had received prior anti-PD-1 or PD-L1 therapy.
Spartalizumab was administered intravenously at a fixed dose of 400 mg once every 4 weeks. NIR178 was given orally in pill form, twice daily at escalating doses of 160 mg, 240 mg, and 320 mg.
By August 2018, 23 (92%) of the patients had discontinued the treatment due to disease progression (13), death for reasons unrelated to the treatment (4), adverse side effects of the treatment (4), and withdrawal of consent to continue in the trial (2). Two patients remained on the treatment.
In 14 other patients who had not received prior anti-PD-1/L1 therapies, one (7%) experienced a complete response to the treatment with the cancer disappearing, a second (7%) had a partial response with the cancer shrinking, and six (43%) had stable disease. In 11 patients who had been pre-treated with anti-PD-1/L1 therapies and experienced a disease progression, eight (73%) had stable disease.
The most frequent treatment-related side effects were nausea, liver problems, fatigue, and an increase in the pancreatic enzyme lipase. Two patients suffered from severe but not life-threatening (grade 3) inflammation of lung tissues. There were no life-threatening (grade 4) treatment-related side effects.
The maximum tolerated dose was determined as 240 mg of NIR178 twice daily and 400 mg of spartalizumab every 4 weeks.
"This was an early phase I/II trial of the combined treatment," said Chiappori. "We believe that observing responses in these heavily pre-treated patients is always a positive sign that represents the potential anti-tumor activity of the regimen and gives a preliminary measure of the importance of continuing to investigate it in further, more definitive studies. The regimen is already being tested in phase II trials of several other solid tumors and non-small cell lung cancer. We are also working on further understanding the mechanism of action of the combination of the two drugs in the body."
Co-Chair of the EORTC-NCI-AACR Symposium, Antoni Ribas, MD, PhD, Professor of Medicine, Professor of Surgery, and Professor of Molecular and Medical Pharmacology at UCLA, commented: "Non-small cell lung cancer is one of the hardest cancers to treat successfully, particularly when it has spread to other parts of the body. Increasingly, we are seeing that drugs that encourage the immune system to attack the cancer may work better together than alone. The results from this early clinical trial suggest that further testing of the combination of NIR178 and spartalizumab is warranted in this type of lung cancer."
2018 EORTC-NCI-AACR SYMPOSIUM ON MOLECULAR TARGETS AND CANCER THERAPEUTICS
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