Central line-associated bloodstream infections (CLABSIs) in U.S. hospitals decreased 50% between 2008 and 2016. The Centers for Disease Control and Prevention attributes this dramatic reduction in infections to a combination of improved central line insertion practices and overall reduced use of central lines, especially in neonatal ICUs. Careful consideration of whether a central line is needed remains a key prevention strategy. Among patients in adult ICUs, reductions in CLABSIs caused by Staphylococcus and Enterococcus species were greater than for infections caused by gram-negative and fungal pathogens. The U.S. Department of Health and Human Services aims for another 50% reduction in CLABSIs by 2020. Read the full report at http://www.cdc.gov/hai/surveillance/data-reports/data-summary-assessing-progress.