Abstract
Background: Randomized clinical trials offer unique opportunities for testing questions of relevance to nursing through the mechanism of ancillary studies.
Approach: A review of the strategies to prepare and negotiate an ancillary study through a randomized clinical trial structure is offered.
Results: Several steps are required that are unique to the ancillary studies arena. These steps involve (a) accessing the main trial; (b) obtaining approval; (c) funding; and (d) publication. There are hurdles and strategies to address them.
Discussion: Collaboration and compromise are the keys to success in the conduct of an ancillary study of scientific merit. The cost-effectiveness, excellent collaboration, and the opportunity to further develop one's research skills and research program in a highly scientific interdisciplinary environment are well worth the effort.