Keywords

chronic obstructive pulmonary disease, Duke Activity Status Index, outcomes, functional capacity, validity, arm ergometry, cycle ergometry, 6-minute walk distance

Authors

1. Carter, Rick PhD, MBA
2. Holiday, David B. PhD
3. Grothues, Carol PhD
4. Nwasuruba, Chiagozie MD
5. Stocks, James MD
6. Tiep, Brian MD

Abstract

PURPOSE: This study evaluated the concurrent criterion validity of the Duke Activity Status Index (DASI) with respect to standard physiologic work capacity indices in patients with chronic obstructive pulmonary disease (COPD) and compared its performance with similar surrogates.

METHODS: 119 patients with moderate to severe COPD (86 men, 33 women) completed medical and smoking histories, physical examination, pulmonary function testing (PFT), cycle ergometry (CE), arm ergometry (AE), and 6-minute walk distance (6MWD), DASI, the Sickness Impact Profile-68 (SIP-68) and the Chronic Respiratory Disease Questionnaire (CRDQ). Correlation methods were used to assess the validity of the potential surrogates DASI and the domain scores for SIP-68 and CRDQ, with the standards CE, AE, PFT, and 6MWD (as a standard).

RESULTS: The mean DASI score was 33.4 +/- 13.0. Significant Pearson correlations (P < .01) were observed between the DASI and PFT outcomes maximum voluntary ventilation (r = .28); peak expiratory flow (r = .21); diffusion capacity of lung for carbon monoxide (r =.30). For CE, the correlations with DASI were oxygen consumption (VO₂)(r = .34); minute ventilation (r = .25); watts (r = .37). For AE, the correlations with DASI were VO₂ (r=.38); watts (r = .47). For 6MWD, the correlation was r = .53. Higher correlations were obtained for the distance completed during the first minute of the 6MWD and ergometric indices as well as DASI scores: watts_AE (r = .39); VO_2AE (r = .45); watts_CE (r = .50); VO_2CE (r = .44). Correlation coefficients for all SIP-68 and CRDQ domain and total scores were lower than corresponding correlations obtained for the DASI. Regression analysis demonstrated that the DASI and 6MWD were important (P < .05) for predicting VO₂ or work for CE while DASI and SIP range or CRDQ dyspnea entered for AE, when gender, age, BMI, and the FEV₁ were forced into the model. In forward stepwise analyses, DASI entered first for AE, and 6MWD entered first for CE. The DASI was selected in 3 of 4 models with R² values ranging from .47 to .70. SIP-68 and CRDQ subscores were significant as additional predictors

CONCLUSIONS: DASI has high criterion validity for predicting CE and/or AE outcomes in the COPD population. It is warranted in addition to the 6MWD, and its predictive significance and simplicity recommends it over several other self-administered instruments for evaluating functional capacity.