Poor oral health, including gum disease and dental problems, was found to be associated with oral human papillomavirus (HPV) infection, which causes about 40 percent to 80 percent of oropharyngeal cancers, according to a study in Cancer Prevention Research.
"Poor oral health is a new independent risk factor for oral HPV infection and, to our knowledge, this is the first study to examine this association," said Thanh Cong Bui, DrPH, a postdoctoral research fellow in the School of Public Health at the University of Texas Health Sciences Center in Houston.
"The good news is, this risk factor is modifiable-by maintaining good oral hygiene and good oral health, one can prevent HPV infection and subsequent HPV-related cancers."
He and his colleagues found that among the study participants, those who reported poor oral health had a 56 percent higher prevalence of oral HPV infection, and those who had gum disease and dental problems had a 51 percent and 28 percent higher prevalence of oral HPV infection, respectively. In addition, the researchers were able to associate oral HPV infections with the number of teeth lost.
The researchers used data from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) conducted by the National Center for Health Statistics of the Centers for Disease Control and Prevention, which is considered to be a nationally representative sample of about 5,000 people recruited each year, located in counties across the United States.
A total of 3,439 participants aged 30 to 69 years were identified for whom data on oral health and the presence or absence of 19 low-risk HPV types and 18 high-risk HPV types in the oral cavity were available. Oral health data included four measures of oral health: self-rating of overall oral health, presence of gum disease, use of mouthwash to treat dental problems within past seven days of the survey, and number of teeth lost. The researchers examined data on age, gender, marital status, marijuana use, cigarette smoking, and oral sex habits, among others, which influence HPV infection.
Being male, smoking cigarettes, using marijuana, and oral sex habits were found to increase the likelihood of oral HPV infection. The team also found that self-rated overall oral health was an independent risk factor for oral HPV infection, because this association did not change regardless of whether or not the participants smoked or had multiple oral sex partners.
As Bui noted in a news release, the theory is that because HPV needs wounds in the mouth to enter and infect the oral cavity, poor oral health, which may include ulcers, mucosal disruption, or chronic inflammation, may create an entry portal for HPV. Further research is needed to fully understand this relationship, he said.