Abstract
Practicing from an evidence-based paradigm requires the practitioner to integrate best available evidence with the patient's preference and values, the clinical context, and the practitioner's clinical expertise. However, the clinician is often at a loss for where to access best evidence. The 6S Model of evidence acquisition can guide the busy practitioner in efficient searching for best available evidence. The article explains the 6S model and the strengths and weaknesses of different types of evidence, while guiding readers with their role as clinicians in ensuring trustworthiness of evidence and relevance to their particular clinical context and patient population.