Authors

1. Nishio, Ryo MD
2. Tanaka, Hidekazu MD, PhD
3. Tsuboi, Yasunori PT, MSc
4. Kinutani, Hiroto MD
5. Taniguchi, Yu MD
6. Shigeru, Mayumi MD
7. Toh, Ryuji MD, PhD
8. Miura, Yasushi MD, PhD
9. Sakai, Yoshitada MD, PhD
10. Emoto, Noriaki MD, PhD
11. Kawai, Hiroya MD, PhD
12. Hirata, Ken-ichi MD, PhD

Abstract

INTRODUCTION: Although pulmonary arterial hypertension (PAH) and chronic heart failure (CHF) lead to exercise limitation, their pathophysiology is different. Our objective was to evaluate, using right heart catheterization and cardiopulmonary exercise testing, the difference in hemodynamic parameters and exercise capacity between PAH and CHF, which have the same subjective symptoms.

METHODS: We studied 20 PAH (mean pulmonary artery pressure: 36 +/- 10 mmHg, all . 25 mmHg) and 20 CHF (ejection fraction: 35 +/- 10%, all < 40%) patients who underwent both cardiopulmonary exercise testing and right heart catheterization. All patients were in New York Heart Association functional class II or III.

RESULTS: Peak oxygen uptake (VO₂) was lower for PAH patients than for CHF patients (11.7 +/- 3.2 mL[middle dot]kg²¹[middle dot]min²¹ vs 14.5 +/- 4.6 mL[middle dot]kg²¹[middle dot]min²¹, P = .03), while the slope of ventilation to carbon dioxide production ratio (VE/VCO₂) was higher for PAH patients than for CHF patients (41.0 +/- 12.7 vs 28.0 +/- 9.0, P = .001), despite the similarity in their New York Heart Association functional class. Peak VO₂ and VE/VCO₂ correlated with cardiac index for both groups. An important finding was that peak VO₂ correlated with pulmonary vascular resistance for PAH patients (r = 20.46, P = .04) but not for CHF patients (r = 0.33, P = .15). Furthermore, peak VO₂ correlated with pulmonary capillary wedge pressure for CHF patients (r = 20.47, P = .03) but not for PAH patients (r = 0.17, P = .47), while the VE/VCO₂ slope correlated with pulmonary capillary wedge pressure (r = 0.67, P = .002) but not with pulmonary vascular resistance (r = 0.12, P = .63) for CHF patients.

CONCLUSION: Peak VO₂ and VE/VCO₂ slope were worse for PAH patients than for CHF patients despite the similar subjective symptoms. This difference might be explained by an altered hemodynamic status.