Abstract
Wernicke-Korsakoff syndrome (WKS) is a disorder of the brain caused by deficiency of thiamine that is common in patients with alcoholism. Thiamine supplementation is a usual treatment in the management of WKS but no standard recommendations have been established. This article discusses the link between supplementation of thiamine and the treatment of WKS in patients with alcoholism, whether thiamine supplementation can improve symptoms of WKS and the current recommendations for thiamine supplementation in managing WKS. Evidence-based research is needed to determine the best thiamine supplementation regimen for patient with WKS.