Abstract
For almost 25 years, the Neonatal Resuscitation Program of the American Academy of Pediatrics has provided educational tools that are used in the United States and throughout the world to teach neonatal resuscitation. Over that time period, the guidelines for resuscitation have been increasingly evidence-based and a formal system has been established to determine which steps should be updated on the basis of available information. The most recent update occurred in 2010. This article describes the evidence review process and the specific evidence that lead to a number of significant changes in practice that were included in the 2010 guidelines.