Keywords

depression, major depressive disorder, pharmacogenetics

Authors

1. Krauter, Roseanne R. BS, RN, FNP
2. Cook, Sarah S. DNP, RN-CS

Abstract

Depression is a chronic disease seen in many healthcare settings. Current pharmacological treatment options are successful in two-thirds of patients. One CYP450 enzyme, CYP2D6, is responsible for the metabolism of 30% of all drugs including many antidepressants. Phenotypes of metabolizer status affect antidepressant treatment outcomes and adverse drug reactions.