Abstract
* Duloxetine (Cymbalta), an antidepressant, is now approved for the treatment of chronic musculoskeletal pain.
* The drug can have serious adverse effects, including liver damage, allergic reactions, pneumonia, and suicidal thoughts and behavior, but these are rare.
* Adverse effects more often seen are nausea, dry mouth, insomnia, drowsiness, constipation, fatigue, and dizziness.