Abstract
This article proposes that inflammation leading to intestinal permeability (a leaky gut) may be responsible for numerous physical and mental abnormalities and associated functional decline. This may be especially true for elderly people, particularly involving the development of autoimmune disorders. In this regard, engagement in appropriate moderate exercise/physical activity can produce an anti-inflammatory effect and may have a powerful role to play as part of a holistic treatment for this potential problem. This is important information for nurses who are interested in integrative and nonpharmacologic care.