isavuconazonium
Cresemba
Pharmaceutical company: Astellas Pharma
NEW FORMULATION
Capsules: 74.5 mg
NEW INDICATION & DOSAGE
Invasive aspergillosis; invasive mucormycosis
Children age 6 to younger than 18 weighing 32 kg or more: Loading doses, 372 mg NG or PO (five 74.5-mg capsules) every 8 hours for six doses (48 hours); followed by 372 mg NG or PO once daily, beginning 12 to 24 hours after last loading dose.
Children age 6 to younger than 18 weighing 25 to less than 32 kg: Loading doses, 298 mg NG or PO (four 74.5-mg capsules) every 8 hours for six doses (48 hours); followed by 298 mg NG or PO once daily, beginning 12 to 24 hours after last loading dose.
Children age 6 to younger than 18 weighing 18 to less than 25 kg: Loading doses, 223.5 mg NG or PO (three 74.5-mg capsules) every 8 hours for six doses (48 hours); followed by 223.5 mg NG or PO once daily, beginning 12 to 24 hours after last loading dose.
Children age 6 to younger than 18 weighing 16 to less than 18 kg: Loading doses, 149 mg NG or PO (two 74.5-mg capsules) every 8 hours for six doses (48 hours); followed by 149 mg NG or PO once daily, beginning 12 to 24 hours after last loading dose.
Children age 3 to younger than 18 weighing 37 kg or more: Loading doses, 372 mg IV every 8 hours for six doses (48 hours); followed by 372 mg IV once daily, beginning 12 to 24 hours after last loading dose.
Children age 3 to younger than 18 weighing less than 37 kg: Loading doses, 10 mg/kg IV every 8 hours for six doses (48 hours); followed by 10 mg/kg IV once daily, beginning 12 to 24 hours after last loading dose.
Children age 1 to younger than 3 weighing less than 18 kg: Loading doses, 15 mg/kg IV every 8 hours for six doses (48 hours); followed by 15 mg/kg IV once daily, beginning 12 to 24 hours after last loading dose.
Released: February 2024
Nursing Drug Handbook
© 2024 Wolters Kluwer
pirtobrutinib
Jaypirca
Pharmaceutical company: Eli Lilly and Company
NEW INDICATION & DOSAGE
Chronic lymphocytic leukemia or small lymphocytic lymphoma in patients who have received at least two prior lines of therapy, including a BTK inhibitor and a BCL-2 inhibitor
Adults: 200 mg PO once daily until disease progression or unacceptable toxicity occurs.
Adjust-a-dose: Refer to the manufacturer's instructions for toxicity-related dosage adjustments. If eGFR range is 15 to 29 mL/minute and the current dose is 200 mg once daily, reduce the dose to 100 mg once daily; otherwise reduce the dose by 50 mg. If the current dose is 50 mg once daily, discontinue the drug. If concomitant use of a strong CYP3A inhibitor can't be avoided, reduce the pirtobrutinib dose by 50 mg. If the current dose is 50 mg once daily, interrupt pirtobrutinib therapy for the duration of the strong CYP3A inhibitor use. After discontinuation of the strong CYP3A inhibitor for five half-lives, the patient may resume the pirtobrutinib dose taken before initiating the inhibitor. If concomitant use with a moderate CYP3A inducer can't be avoided and the current dose of pirtobrutinib is 200 mg once daily, increase the dose to 300 mg. If the current pirtobrutinib dose is 50 mg or 100 mg once daily, increase the dose by 50 mg.
Released: February 2024
Nursing Drug Handbook
© 2024 Wolters Kluwer