Use of potentially inappropriate medications (PIMs) in older adults has increased worldwide over the past two decades, according to a recent meta-analysis with over 371 million participants from 17 countries published in the August JAMA Network Open. The authors found that 37% of older adults were using a medication that placed them at risk for adverse effects that outweigh the expected benefits. The highest prevalence was in Africa and South America, both at 47%. The authors note that Africa is the only region without PIMs criteria and South America has a high prevalence of multimorbidity, known to increase the likelihood of PIM use. The prevalence in North America was 29%, below rates in Asia (37%) and Europe (35%). Polypharmacy and age greater than 80 years increased the likelihood of PIM use. Additionally, the authors found that the prevalence of PIM use is "roughly opposite to the national economic level." They attributed this to better medical systems, availability of health insurance, and establishment of geriatric medicine in countries with better economic conditions.