Antibiotic resistance is a growing threat. Antibiotic resistant infections were responsible for more than 35,000 deaths out of 2.8 million cases, according to the Centers for Disease Control and Prevention's report, Antibiotic Resistance Threats in the United States, 2019. Currently, 18 bacteria and fungi present an urgent, serious, or concerning threat of antibiotic resistance. Another urgent threat is Clostridioides difficile (formerly Clostridium difficile), with 223,900 cases and 12,800 deaths in 2017. Two alarming trends were noted: first, the rising rates of resistant infections at the community level, where it is more difficult to track than in health care settings and can spread more widely; and second, the new forms of resistance, particularly the sharing of resistant genes among antibiotic-resistant organisms. However, a decrease in the number of deaths from antibiotic resistant infections since the 2013 report is evidence that efforts to address antibiotic resistance are working, especially in hospitals. For more, see http://www.cdc.gov/drugresistance/biggest-threats.html.