The volume of infusion therapy services provided in the long-term care setting has declined. One major influence has been the changes in reimbursement experienced in this sector of the industry. This article is intended to stimulate the long-term care clinician to reexamine the service offered and to be creative in his or her approach to building infusion services. The article also explores parallels to the home infusion industry, which has evolved through similar changes, with the intent of learning from its experiences.