March 2006, Volume 36 Number 3 , p 20 - 21
ROSENTHAL, KELLI RN, BC, ANP, APRN, BC, CRNI, MS
ADMINISTERED I.V., immune globulin (IGIV) can help treat or prevent certain diseases when the patient's own immune system isn't up to the task. Immunoglobulins, or antibodies, come in five forms, each with its own structure and function. All five immunoglobulins are contained, in varying amounts, in commercially prepared IGIV.
The approved indications for IGIV vary by brand, but in general IGIV is approved for primary immunodeficiencies, immune-mediated thrombocytopenia, Kawasaki syndrome, hematopoietic stem cell transplantation in patients older than 20 (Gamimune N only), B-cell chronic lymphocytic leukemia, and pediatric HIV type 1 infection. However, up to 70% of patients who receive IGIV are given it for an off-label indication, such as myasthenia gravis.
How IGIV works
Immune globulin confers passive immunity through antibodies present in the pooled donor plasma that goes into IGIV products. Donors are thoroughly screened, ...