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March 2010, Volume 40 Number 3 , p 17 - 17



Researchers suggest that angiotensin receptor blockers (ARBs), commonly used to treat hypertension and heart failure, may decrease the risk of developing Alzheimer disease and dementia.Over a 4-year period, researchers studied 819,491 mostly male patients age 65 and older with cardiovascular disease taking ARBs, the angiotensin-converting enzyme (ACE) inhibitor lisinopril, or other cardiovascular drugs (the cardiovascular comparator). They found that those taking ARBs, especially candesartan, were significantly less likely to develop Alzheimer disease or dementia than patients in the other groups. In patients with preexisting Alzheimer disease, ARBs were associated with a significantly lower risk of admission to a long-term-care facility or death when compared with the cardiovascular comparator.Source: Li N, Lee A, Whitmer RA, et al. Use of angiotensin receptor blockers and risk of dementia in a predominately male population: prospective cohort analysis. Brit Med J. 2010;340:b5465.Recent

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