March 2008, Volume 38 Number 3 , p 15 - 15
MOST I.V. DRUGS are compatible with commonly used I.V. solutions. But the more complex the solution, the greater the risk of incompatibility : an undesirable chemical or physical reaction between a drug and a solution or between two or more drugs.
Physical incompatibility occurs more commonly with multiple additives. Signs of this type of incompatibility can be seen in the solution and include precipitation, haze, gas formation, and cloudiness. Solutions that contain calcium (such as lactated Ringer's solution) are more likely to form precipitate if a drug is added.
Chemical incompatibility occurs when mixing two drugs changes the potency of their active ingredients. A drug that loses more than 10% of its potency when mixed with another ...