October 2007, Volume 37 Number 10 , p 60 - 61
Gendreau-Webb, Rosalyn RN, BSN
Rosalyn Gendreau-Webb is project manager at Maine Digestive Disease Health Center at the Maine Medical Center in Portland.
MANY PEOPLE with gastroesophageal reflux disease (GERD) treat themselves with over-the-counter (OTC) drugs such as antacids that neutralize stomach acid. Or they may choose a proton pump inhibitor (PPI) or a histamine 2 -receptor antagonist (H 2 -RA)—both available OTC and advertised widely in print and on TV. ( See How do these drugs work ? for a comparison of PPIs and H 2 -RAs.) But are these two options equally safe?
In the past year, two major research studies have connected PPI use to an increased risk of fractures, especially hip fractures. 1 , 2 In this article, I'll tell you how to help your patient who has GERD with education, dietary changes, diagnostic testing, and possibly medication changes to prevent PPI-associated fractures.
Studies reveal risks
The study ...