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January 2013, Volume 43 Number 1 , p 9 - 9



In a double-blind, double-placebo-controlled trial, researchers compared oral anticholinergic therapy with onabotulinumtoxinA injections to treat women with idiopathic urgency urinary incontinence. The participants had experienced five or more episodes of urgency urinary incontinence per 3-day period, as documented in patient diaries. The primary outcome at 6 months was a reduction in the daily average of urgency urinary incontinence incidents. Secondary outcomes included resolution of urgency urinary incontinence, quality of life, catheter use, and adverse events.In the oral anticholinergic group, the average reduction in incidents of urgency urinary incontinence from baseline (5.0 per day) was 3.4, compared with 3.3 in the onabotulinumtoxinA injection group. Resolution of urgency urinary incontinence was 13% and 27%, respectively.Researchers found that oral anticholinergic medications and onabotulinumtoxinA injections were associated with "similar reductions" in daily urgency urinary

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