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November 2011, Volume 41 Number 11 , p 26 - 26



According to the FDA, dosages of the selective serotonin reuptake inhibitor citalopram shouldn't exceed 40 mg/day because it can cause cardiac conduction abnormalities. Higher doses of this antidepressant medication can trigger dose-dependent QT interval prolongation, possibly leading to life-threatening dysrhythmias such as torsade de pointes. Patients with underlying heart disease (such as heart failure or bradydysrhythmias) and those predisposed to hypomagnesemia and hypokalemia are at particular risk.Labeling for citalopram has been revised to reflect this new recommendation. Previously, the label stated that certain patients may require 60 mg/day, but studies haven't shown a treatment benefit at doses over 40 mg/day. Healthcare providers are encouraged to report any adverse reactions related to the use of citalopram to the FDA's MedWatch Safety Information and Adverse Event Reporting Program.Source: U.S. Food and Drug Administration. Celexa (citalopram hydrobromide): Drug Safety Communication-Abnormal

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