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October 2010, Volume 40 Number 10 , p 14 - 14



Evaluating the effects of antidepressants on pregnant women, researchers have found an association between the risk of miscarriage and certain antidepressants.Using data on 5,124 women who had a clinically detected miscarriage, researchers noted that 284 (5.5%) had filled a prescription for an antidepressant during their pregnancy. These antidepressants included selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors.Analysis of the data showed that the use of antidepressants during pregnancy was associated with an increased risk of miscarriages. Further analysis showed that use of the SSRI paroxetine alone, the SNRI venlafaxine alone, or the combined use of antidepressants from different classes was especially associated with an increased risk of miscarriage. The researchers advise healthcare providers with patients of childbearing potential who are taking antidepressants or

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